Azoliums and Ag(I)‐N‐Heterocyclic Carbene Thioglycosides: Synthesis, Reactivity and Bioactivity

A versatile protocol for the synthesis of azolium thioglycosides is reported. This based on a PdG3-catalyzed Migita cross-coupling between p-di-iodo azoliums and protected or unprotected β-1-thioglucose partners. Moreover, solvent-free mechanochemistry approach was developed as unique access to corresponding Ag(I)-N-heterocyclic carbene thioglycosides. Finally, chemical reactivity antiproliferative bioactivity were examined with Ag(I)-NHC study demonstrates promising potential these newly synthesized carbohydrate-based N-heterocyclic derivatives.